Unfortunately, it is not possible to delete profiles out of CRM because it might cause data consistency issues. Moreover, deleting profiles from CRM is pretty much meaningless because Linked Helper adds every profile into the CRM during the collecting process.
However, you can mark such contacts with a "deleted" tag and then use built-in filters to sort them out.
By setting up the "Hasn`t Tags" filter as per the screenshot below you will not see manually "deleted" profiles:
Also, you can use this tag later to exclude people from your campaigns: